A SYSTEM WHICH CAN “TUNE” DRUGS
TO PERFECT THEM INTO MORE POTENCY
ABOUT THE PROJECT
Traditionally our research is focused to organic and hybrid systems used as dyes, indicators, sensing and NLO materials. Molecular spectroscopy (UV-Vis-NIR, IR/ Raman, fluorescence, NMR and mass spectrometry) and quantum chemistry are used as tools.In other words we are on the border between physical organic and organic analytical chemistry, depending on the viewpoint.
ABOUT THE TEAM
Inter and IntraMolecular Processes (I2MP) Group has been created in 2007 after the group leader had been appointed as Senior Research Associate in Organic Chemistry at The Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences. The group continues the development of The UV-Vis Spectroscopy and Chemometrics Group (National Forestry University, Sofia).
GROUP MEMBERS
Liudmil Antonov
Dr Vera Deneva
Dr Atanas Kurutos
Yana Manolova
Nevse Molla
Dinko Stoikov
Silvia Hristova
Daniela Ivanova
Nikola Dimitrov
Research Director
Assistant Professor
Assistant Professor
Assistant Professor
PhD student (1st year)
PhD student (1st year)
MSc student (Sofia University)
MSc student (Sofia Medical University)
BSc student (Sofia University)
ALUMNI
Vesselin Petrov, PhD student (Spectroscopy/Chemometrics),
currently at University of Lisboa, Portugal
Sonya Damyanova, Collaborator (Ecology),
currently at University of Forestry, Bulgaria
Maya Nikiforova, PhD student (Optical sensors),
currently at DansPharma, Bulgaria
Boriana Cavicchia, MSc student (Tautomeric dyes),
currently at American Red Cross
Dimitar Dimitrov, MSc student (Aggregation of Dyes)
LIUDMIL ANTONOV, PHD, DRSCI
Bulgarian Academy of Sciences
BAS · Emil Djakov Institute of Electronics
Liudmil Antonov currently works at the Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences. Liudmil does research in Analytical Chemistry, Physical Organic Chemistry and Spectroscopy. The current projects are based on the tautomerism of organic compounds.
MEMBERSHIPS
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European Photochemical Association
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Tokyo Institute of Technology Alumni Association
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Bulgarian Humboldt Union
-
Union of Scientists in Bulgaria
RESEARCH INTERESTS
Quantum chemistry
(relative stability of equilibrium systems, solvent effects, absorption and emission spectra prediction)
Molecular Spectroscopy
(UV-Vis-NIR, fluorescence, mass spectrometry)
Chemometrics
(including derivative spectroscopy and overlapping bands fitting)
Tautomerism
(experimentally and computationally)
Supramolecular chemistry
(host-guest interactions, molecular switches and wires, sensoring systems)
Dye chemistry
(design and properties – photochromism, thermochromism, halochromism, solvatochromism, aggregation)
COLLABORATIONS
Prof. Mariana Mitewa
(University of Sofia, Faculty of Chemistry, since 1992) – coordination chemistry
Prof. Susumu Kawauchi
(Tokyo Tech, Department of Organic and Polymeric Materials, since 1995) – quantum chemistry
Prof. Poul Erik Hansen and Dr. Fadhil S. Kamounah
(University of Roskilde, Department of Science, Systems and Models, since 1997) - tautomerism of Schiff bases
Prof. Walter M.F. Fabian
(University of Graz, Institute of Chemistry, since 1998) – tautomerism
Prof. Gert van der Zwan
(Vrije University Amsterdam, Department of Chemistry and Pharmaceutical Sciences, since 1998) - proton transfer
Prof. Koji Ohta and Dr. Kenji Kamada
(National Institute of Advanced Industrial Science and Technology, Research Institute for Ubiquitous Energy Devices, since 2002) - NLO materials
Prof. Jakob Wirz
(Univertsity of Basel, Departement Chemie, since 2005) – flash photolysis
Prof. Katharina M. Fromm
(University of Fribourg, Chemistry Department, since 2007) - crystallography
Prof. Stefan Lochbrunner
(University of Rostock, Institute of Physics, since 2011) – dynamics of proton transfer
Prof. Christoph Schalley
(Free University of Berlin, Institute of Chemistry and Biochemistry, since 2012) – supramolecular chemistry
Prof. Carlo Adamo
(ParisTech, since 2014) – excited state proton transfer
SOFTWARE
STEP BY STEP FILTER
Smart approach to increase the information, which can be extracted by using derivative spectroscopy
FISHING-NET ALGORITHM
Program for resolution of overlapping bands and quantitative spectral analysis of undefined (with unknown individual spectra of the components) mixtures
MARCUS FITTING
Program for resolution of charge transfer absorption/ emission bands