A SYSTEM WHICH CAN “TUNE” DRUGS
TO PERFECT THEM INTO MORE POTENCY
ABOUT THE PROJECT
Traditionally our research is focused to organic and hybrid systems used as dyes, indicators, sensing and NLO materials.Molecular spectroscopy (UV-Vis-NIR, IR/ Raman, fluorescence, NMR and mass spectrometry) and quantum chemistry are used as tools.In other words we are on the border between physical organic and organic analytical chemistry, depending on the viewpoint.
Our interest is directed to the design of dyes for sensing and high-tech applications and to the spectral properties of dyes in solution and solid state. Many types of colour properties related phenomena (aggregation, tautomerism, halochromism, thermochromism, solvatochromism, complexation, NLO activity) have been studied during the years.
Solvent effects on the second-order nonlinear optical responses in the keto−enol equilibrium of a 2-hydroxy-1-naphthaldehyde derivative. E.Bogdan, A.Plaquet, L.Antonov, V.Rodriguez, L.Ducasse, B.Champagne & F.Castet; Journal of Physical Chemistry, 114C, 12760 (2010)
Exploiting the tautomerism for switching/signaling purposes. L.Antonov, V.Deneva, S.Simeonov, V.Kurteva, D.Nedeltcheva & J.Wirz; Angewandte Chemie International Edition, 48, 7875 (2009)
A systematic femtosecond study on the two-photon absorbing D-pi-A molecules - pi-bridge nitrogen inseprtion and strength of the donor and acceptor groups. L.Antonov, K.Kamada, K.Ohta & F.S.Kamounah; Physical Chemistry Chemical Physics, 5, 1193 (2003)
Temperature dependent absorption spectroscopy of some tautomeric azodyes and Schiff bases. H.Joshi, F.S.Kamounah, G.van der Zwan, C.Gooijer & L.Antonov; JCS Perkin Transactions 2, 2303 (2001)
Aggregation and tautomeric properties of C.I. Acid Red 138. T.Iijima, E.Jojima, L.Antonov, S.Stoyanov & T.Stoyanova; Dyes & Pigments, 37, 81 (1998)
STEP BY STEP FILTER
Smart approach to increase the information, which can be extracted by using derivative spectroscopy
Program for resolution of overlapping bands and quantitative spectral analysis of undefined (with unknown individual spectra of the components) mixtures
Program for resolution of charge transfer absorption/ emission bands